Multiple Myeloma
Multiple myeloma exhibits profound molecular heterogeneity across plasma cell differentiation, tumor-microenvironment interactions, cytogenetic subgroups, and pathway dependencies — requiring integrated, multi-dimensional analysis.
Biological Heterogeneity in Myeloma
Plasma Cell Differentiation Spectrum
Myeloma cells are arrested at various stages of B-cell to plasma cell differentiation. The stage of arrest — from pre-plasmablast to mature plasma cell — profoundly influences disease behavior, molecular vulnerability profiles, and biological progression.
Tumor-Microenvironment Interactions
The bone marrow microenvironment — including immune cell populations, stromal interactions, and cytokine signaling — plays a central role in myeloma biology. Paired tumor and TME profiling provides a more complete picture than tumor-only analysis.
Cytogenetic & Molecular Diversity
Translocations, hyperdiploidy, and specific mutations create diverse molecular contexts with distinct biological and translational relevance. Integrating cytogenetic risk with transcriptomic and proteomic data reveals deeper biological structure than any single data modality alone.
Functional States
Through multi-omics integration, Helomnix identifies interpretable functional states in myeloma that reflect:
Questions the Digital Twin Supports
Helomnix digital twins provide structured biological representations for research and translational support. They are not intended for clinical decision-making.