Acute Myeloid Leukemia
AML is one of the most heterogeneous human cancers — characterized by complex clonal architectures, differentiation hierarchies, and diverse pathway dependency patterns that require multi-dimensional biological analysis.
Biological Heterogeneity in AML
Clonal Architecture
AML tumors harbor multiple co-existing clones with distinct mutation profiles, creating a complex evolutionary landscape that influences disease trajectory and relapse dynamics. Standard classification based on individual driver mutations provides a partial view of this complexity.
Differentiation Hierarchy
Leukemic cells span a spectrum of differentiation states — from stem-like progenitors to more mature myeloid forms — each with distinct preclinical response profiles and functional properties. Understanding where a patient sits in this landscape is essential for biological interpretation.
Microenvironment & Immune Context
The bone marrow microenvironment plays a critical role in AML biology, influencing compound resistance mechanisms, immune evasion, and disease progression. Integrated analysis of tumor and microenvironment is required for a complete biological picture.
Functional States
Through multi-omics integration, Helomnix identifies interpretable functional states in AML that reflect:
Questions the Digital Twin Supports
Helomnix digital twins provide structured biological representations for research and translational support. They are not intended for clinical decision-making.